Mozart Memberikan Hasil Indeks Apoptosis Lebih Rendah daripada Musik Pop, Religi dan Tanpa Pemberian Musik

Dian Sukmawati, Hermanto Tri Juwono, Widjiati Widjiati

Abstract


Background: Brain growth requires genetic potential for a conducive environment, low stress levels, stimulation and nutrition. Brain development during the fetal period in the two years of life firstly requires proper stimulation to increase intelligence. Classical music stimulation has been proven to be able to optimally improve brain function and human intellect. Other music that Indonesian people like is pop and religion. Maybe it is possible to pop and religious music can affect the development and growth of the fetal brain. Objective: Analyze the differences of the index of apoptosis Cerebrum and Cerebellum Rattus norvegicus newborn between those stimulated by Mozart, pop, religious music and not stimulated by music during pregnancy. Method: This study was post test only control group design. groups were randomly divided according to the treatment as stimulation of Mozart, pop, religious music and no music was given from the 10th day-gestation with an intensity of 65 dB in a soundproof box for one hour. When 19th day-gestation, Rattus norvegicus mothers were sacrificed then 3 Rattus norvegicus newborn from each mothers were selected and brain was taken to be made immunohistochemical preparations and counted the number of neuron cells apoptosis index. data were analyzed by comparison test with p <0.05. Results: There was a significant difference in the cerebrum neuron apoptosis index newborn between groups p = 0.001 but there was no difference between without exposure and pop music groups p = 0.063 (the lowest mean was the mozart group 2.40 IRS) and there was also difference in the apoptosis index in the cerebellum p = 0,000 but there was no difference between pop music and without exposure group p = 0.151 (the lowest mean was the mozart group 2.34 IRS) Conclusion: Mozart gives a lower apoptotic index than pop music, religion and without exposure music group.
Keywords: neuron apoptosis index; mozart mucic; pop music; religion music
ABSTRAK

Latar Belakang: Tumbuh kembang otak membutuhkan potensi genetik lingkungan yang kondusif, tingkat stres yang rendah, stimulasi dan nutrisi. Perkembangan otak selama periode janin dan dua tahun pertama kehidupan memerlukan stimulasi yang tepat untuk meningkatkan kecerdasan. Stimulasi musik klasik terbukti dapat meningkatkan fungsi otak dan intelektual manusia secara optimal. Musik lain yang suka didengarkan oleh masyarakat Indonesia adalah pop dan religi. Kemungkinan musik pop dan religi juga dapat mempengaruhi perkembangan dan pertumbuhan otak janin. Tujuan: Menganalisis perbedaan indeks apoptosis Cerebrum dan Cerebellum Rattus norvegicus baru lahir antara yang di stimulasi musik Mozart, pop, religi dan tidak di stimulasi musik selama kebuntingan. Metode: Penelitian ini adalah post test only control grup design. kelompok dibagi secara acak disesuaikan dengan perlakuan yaitu pemberian musik Mozart, pop, religi dan tidak diberikan musik sejak hari ke-10 kebuntingan dengan intensitas 65 dB dalam kotak kedap suara selama satu jam. Kehamilan hari ke 19 tikus bunting dikorbankan, anak tikus dipilih 3 ekor tiapinduk diambil otaknya, dibuat sediaan imunohistokimia dan dihitung jumlah sel neuron yang mengalami apoptosis. Hasil dianalisis uji perbandingan dengan komparasi p<0,05. Hasil: Terdapat perbedaan bermakna indeks apoptosis cerebrum Rattus norvegicus baru lahir antar kelompok p=0,001 namun tidak ada perbedaan kelompok tanpa paparan dengan musik pop p=0,063 (mean terendah adalah kelompok mozart 2,40 IRS) dan terdapat perbedaan indeks apoptosis di cerebellum dengan nilai p=0,000 namun tidak ada perbedaan kelompok tanpa paparan dengan musik pop p=0,151 (mean terendah adalah kelompok mozart 2,34 IRS) Kesimpulan : Mozart memberikan hasil indeks apoptosis lebih rendah dari musik pop, religi dan tanpa pemberian musik.
Kata kunci: Indeks apoptosis; musikmozart; musik pop; musik religi

Keywords


Indeks apoptosis, mozart, pop, religi.



DOI: http://dx.doi.org/10.33846/sf.v11i1.595

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