Penetapan Total Flavonoid, Aktivitas Antioksidan dan Karakterisasi Nanopartikel Ekstrak Etanol Daun Kelor (Moringa pterygosperma Gaertn.)

Tinta Julianawati

Abstract


Moringa pterygosperma is one of the plants in Indonesia that is often used in herbal medicine. Moringa leaves contain many phytochemical compounds, one of the compounds is flavonoids which function as antioxidants. Flavonoid compounds in vitro can inhibit lipid peroxidation by breaking the chain of peroxyl radicals. Moringa leaf benefits in the field of herbal medicine are formed with a variety of preparations. One of the preparations is in the form of extracts with the aim of attracting chemical components to natural materials The extraction process has a disadvantage because the level of solubility in water is still low. The nanoparticle technique is a strategy to increase the bioavalbicibility of herbal active compounds. This research is experimental in order to determine the total flavonoid levels contained in Moringa leaf extract. In addition, it is also to find out the antioxidant activity and particle size of the moringa leaf extract nanoparticles. Determination of flavonoid levels using spectrophotometric methods. The antioxidant activity of moringa leaf extract nanoparticles was tested using the DPPH method (2,2-diphenyl-picrylhdrazyl) and to determine the particle size used by using the Particle Size Analyzer (PSA). The results of the study showed total flavonoid levels in moringa leaf extract (1.97 ± 1.07)%. Antioxidant activity of 451.8 ppm with a reduction of 2.8% and particle size in the moringa leaf extract nanoparticles of ± 134.78 nm. Moringa leaf extract nanoparticles include low antioxidants.
Keywords: Moringa; nanoparticles;antioxidants

References


Aminah , Nurhayati Tomayahu, Zainal Abidin. Penetapan Kadar Flavonoid Total Ekstrak Etanol Kulit Buah Alpukat (Persea Americana Mill.) Dengan Metode Spektrofotometri Uv-Vis.Jurnal Fitofarmaka Indonesia. 2013;4(2)

Azizah Dyah Nur, Endang Kumolowati,dan Fahrauk Faramayuda. Penetapan Kadar Flavonoid Metode Alcl3 Pada Ekstrak Metanol Kulit Buah Kakao (Theobroma Cacao L)Kartika Jurnal Ilmiah Farmasi. 2014;2(2):45-49

Bolhassani Azam, Shabnam Javanzad,Tayebeh Saleh, Mehrdad Hashemi,and Mohammad Reza Aghasadeghi.Nanoparticles Potent Vectors For Vaccine Delivery Targeting Cancer And Infectious Diseases. Human Vaccnes & Immunoterapeutics. 2014;10(2):321–332.

Dai1,Masamitsu Tanaka and Ying-Ying Huang. Chitosan Preparations For Wounds And Burns: Antimicrobial And Wound-Healing Effects . Expert Rev Anti Infect Ther. 2011;9(7): 857–879

Gupta S,Lucky Sekhon,Yesul K And Ashok. The Role Of Oxidative Stress And Antioxidants In Assisted Reproduction. Current Women`S Health Reviews. 2010;(6):227-238

Husniati Dan Eva Oktarina.Sintesis Nano Partikel Kitosan Dan Pengaruhnya Terhadap Inhibisi Bakteri Pembusuk Jus Nenas. Jurnal Dinamika Penelitian Industri . 2014;25(2)

Li Jianghua, Chao Cai,Jiarui Li, And Guangli Yu. Chitosan-Based Nanomaterials For Drug Delivery. J.Molecules. 2018;23(10):2661

Mauizatul Hasanah, Bella Maharani,dan Ensiwi Munarsih. Daya Antioksidan Ekstrak Dan Fraksi Daun Kopi Robusta (Coffea Robusta) Terhadap Pereaksi Dpph (2,2-Difenil-1-Pikrilhidrazil). Indonesian Journal Of Pharmaceutical Science And Technology.2017; 4:(2)

Pakki Ermina, Sumarheni, Aisyah F, Ismail, dan Syarfina Safirahidzni. Formulasi Nanopartikel Ekstrak Bawang Dayak (Eleutherine Americana (Aubl) Merr) Dengan Variasi Konsentrasi Kitosantripolifosfat (TPP). J. Trop. Pharm. Chem. 2016;3(4)

Palvai Vanitha Reddy, Sowmya Mahalingu, and Asna Urooj. Abrus Precatorius Leaves: Antioxidant Activity In Food And Biological Systems, pH, And Temperature Stability. International Journal Of Medicinal Chemistry.2014

Prasetiowati Agung Tri Prasetya, dan Sri Wardani. Sintesis Nanopartikel Perak Dengan Bioreduktor Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Sebagai Antibakteri.Indo. J. Chem. Sci. 2018;7(2)

Patabang , Syahruddin Kasim , dan Paulina Taba. Sintesis Nanopartikel Perak Menggunakan Ekstrak Daun Kluwak Pangium edule Reinw Sebagai Bioreduktor dan Uji Aktivitasnya Sebagai Antioksidan. Jurnal Ilmu Alam dan Lingkungan.2019;10(1):42-50

Rizkayanti, Anang Wahid. M. Diah dan Minarni Rama Jura. Uji Aktivitas Antioksidan Ekstrak Air Dan Ekstrak Etanol Daun Kelor (Moringa Oleifera Lam) Antioxidant Activity Tests Of Water And Ethanol Extracts Of Moringa (Moringa Oleifera Lam) Leaves. J. Akad. Kim. 2017;6(2): 125-131

Rizvi Syed A.A. and Ayman M. Saleh. Applications Of Nanoparticle Systems In Drug Delivery Technology.Elsevier. 2018;26(1):64–70.

Sumarlin La Ode,Agik Suprayogi,Min Rahminiwati dan Achmad Tjahja. Bioaktivitas Ekstrak Metanol Daun Namnam Serta Kombinasinya Dengan Madu Trigona. J.Teknologi Dan Industri Pangan. 26(2):144-154

Ulayya Hanidya Fidela, Yuniar Ayu Limantini Suwele, Erika Indah Junior, dan Nisia Anindita Rinjani. Pemanfaatan Lendir Bekicot Afrika (Achatina Fulica) Sebagai Obat Luka Bakar Berbasis Nanoemulsi. Jurnal Ilmiah Farmasi. 2018;6(2):91-94

Vergara Marcella,Manal Mused Almatrafi, and Maria Luz Fernandez. Bioactive Components In Moringa Oleifera Leaves Protect Against Chronic Disease. J.Antioxidant. 2017;6(4):91

Zulfa , Nurkhasanah , dan Laela Hayu. Aktivitas Antioksidan Sediaan Nanopartikel Kitosan Ekstrak Etanol Rosela (Hibiscus Sabdariffa L.) Pada Tikus Hiperkolesterol Terhadap Aktivitas Enzim SOD. Kartika Jurnal Ilmiah Farmasi. 2014;2(1):7-14




DOI: http://dx.doi.org/10.33846/sf.v11i1.616

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